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CXCR


CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span the cell membrane seven times. There are currently seven known CXC chemokine receptors in mammals, named CXCR1 through CXCR7.

  • NVP CXCR2 20 EI1973

    NVP CXCR2 20是活性选择性 CXCR2 拮抗剂。

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  • IT1t dihydrochloride EI1372

    IT1t dihydrochloride是活性的 CXCR4 拮抗剂。

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  • SB225002 EY0819

    SB225002是趋化因子受体CXCR2高校选择性抑制剂，IC50值为22nM，对CXCR1及其他7-TMRs跨膜受体抑制力弱或无。

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  • Plerixafor EY0683

    Plerixafor (AMD3100)是一种CXCR4趋化因子受体拮抗剂，抑制CXCR4和CXCL12调节的趋化性，IC50分别为44 nM和5.7 nM。

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  • Plerixafor 8HCl EY0548

    Plerixafor八盐酸盐是CXCR4趋化因子受体拮抗剂，能够拮抗CXCR4和CXCL12调节的趋化作用， IC50分别为44 nM和5.7 nM。

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